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Lactoferrin: a first-line immune defence protein

Lactoferrin from Cow's Milk PUREnFERRIN™ is prepared directly from fresh cow’s milk that has passed through our innovative manufacturing process.

What is Lactoferrin?

Lactoferrin is an exciting natural adjunct to nutritionally support the immune system. Lactoferrin was first reported in 1960. It is a non-haemic iron-binding protein and is a member of the transferrin family (reference).

Lactoferrin is an 80 kDa glycosylated protein of approximately 700 amino acids (reference, reference) comprised of a simple polypeptide chain folded into two symmetrical lobes (reference). Lactoferrin is found in mucosal secretions including neutrophils (reference), milk and colostrum, tears, saliva, nasal and bronchial secretions, bile, gastrointestinal fluids, vaginal fluids, semen, and urine (reference).

Lactoferrin's role as a first-line immune defence protein

Lactoferrin is considered a first-line defence protein involved in immune response (reference) and the protection against a variety of microbial infections (reference, reference). It has antibacterial (Gram+ and Gram-), antiviral, and antimicrobial properties (reference) and has benefits in the gut (reference). One of the immune mechanisms of lactoferrin involves iron sequestration in sites of infection (reference, reference), which deprives microorganisms of this iron and causes a bacteriostatic effect (reference).

Its role as an antioxidant 

Oxidative stress occurs when the production of potentially destructive reactive oxygen species (ROS) exceeds the body's own natural antioxidant defences and results in cellular damage (reference). Lactoferrin can function as an antioxidant, reduce intracellular levels of reactive oxygen species, reduce oxidative stress, and reduce excess inflammatory responses (reference, reference, reference). Lactoferrin may be a useful tool in conditions with oxidative stress. Increased ROS leads to exacerbated inflammation (reference). Lactoferrin plays a role in the prevention of systemic inflammation (reference).

Its role in iron regulation 

Lactoferrin plays a key role in maintaining cellular iron levels in the body (reference). This is via the regulation of the absorption of iron (reference) and the homeostasis and transportation of iron (reference, reference, reference). Lactoferrin possesses a greater iron-binding affinity. It is the only transferrin with the ability to retain this iron over a wide range of pH values, including resistance to proteolysis (reference).



PUREnFERRIN™ is a unique ultra-premium lactoferrin that is a rapidly absorbed high purity lactoferrin protein. 
PUREnFERRIN™ is prepared directly from fresh cow's milk that has passed through our innovative manufacturing process designed to minimise protein denaturation, and so optimise the preservation of the natural state of the Lactoferrin protein and its functional properties.

PurenFerrin Features and Benefits

  • Proudly Australian made using pure Australian cow's milk
  • Optimised lactoferrin protein preservation
  • Gently spray dried at low temperatures
  • Smaller, more uniform lactoferrin particles permit improved blending and solubility outcomes
  • The manufacturing facility has sustainability features, such as Victoria's largest solar roof battery pack
Lactoferrin can be used in tablets, capsules, and powders.

This is presented for informational purposes only. You should not rely on this information as a substitute or replacement for professional medical advice, diagnosis, or treatment. This website includes links to other websites. These links are provided for your convenience only and do not mean that we endorse these sites or the products and services they provide. You acknowledge and agree that we are not responsible or liable for the content or accuracy of these other sites. CMG and its staff do not claim to treat or cure any health conditions mentioned. Always read the label. Follow the directions for use. If symptoms persist, talk to your health professional.
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